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KMID : 0376219990350010061
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Chonnam Medical Journal
1999 Volume.35 No. 1 p.61 ~ p.68
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Oxidation of the Sulfhydryl Group by Cephalosporins
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Song Dong-Up
Choi Kee-Oh
Jung Young-Do
Kim Yeon-Jong
Yang Sung-Yeul
Lee Min-Wha
Ahn Bong-Whan
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Abstract
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To investigate the mechanism for the adverse reactions of cephalosporins, their ability to oxidize reduced glutathione(GSH) and other sulfhydryl compounds was examined. All the six kinds of cephalosporins used could oxidize GSH to GSSG. At the same molar concentration, the cephalosporins showed the following order of potencies in oxidizing GSH : moxalactam > cefsulodin > cephalothin > cephaloridine > cephapirin > cefotaxime. The oxidation of GSH by cephalosporins increased in a concentration-dependent manner. Moxalactam was shown to readily oxidize not only GSH but also dithiothreitol and cysteine. Moxalactam could also oxidize the sulfhydryl group of ovalbumin in the presence of sodium dodecyl sulfate, but it could not oxidize the sulfhydryl group of human serum albumin and human blood plasma in the native condition. Human serum albumin and blood plasma could inhibit the GSH oxidation by moxalactam. The above results suggest that oxidation of the sulfhydryl group of GSH and some proteins may be involved in the adverse reactions of cephalosporins.
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KEYWORD
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cephalosporin, oxidation, sulfhydryl group
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